Abstract
Common over-the-counter medications such as ibuprofen, loratadine, and naproxen inhibit glucuronosyl transferase, which are responsible for the metabolism and promoting excretion of phthalates, ubiquitous industrial chemicals and environmental pollutants. Existing studies on phthalate diesters and their monoester metabolite concentrations in humans have shown individual metabolism of phthalates varies both between and within individuals, but the etiology of this inter- and intra-individual variation remains unknown. Glucuronosyl transferase inhibition by over-the-counter medications may affect individual phthalate metabolism, and therefore may explain these patterns. In the following study, novel liquid chromatography tandem mass spectrometry and solid phase extraction methods were developed to quantify over-the-counter medication levels in human urine. This method development was completed in tandem with data analysis of human urine samples of known phthalate monoester levels, with the ultimate purpose of these studies being the assessment of over-the-counter medications in individual human metabolism of phthalates.
How to Cite
Way, M., (2018) “Development Of A Liquid Chromatography Tandem Mass Spectrometry Method For The Detection And Quantification Of Eleven Common Over-The-Counter Medications In Human Urine”, Capstone, The UNC Asheville Journal of Undergraduate Scholarship 31(1).
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