Abstract
The world is facing an antibiotic resistance crisis that will result in millions of deaths across the world per year if current trends continue. In the United States alone, about 2.8 million people contract an antibiotic resistant infection per year. This current health emergency has established that there is a need for the discovery and development of new effective antibiotics to treat multidrug resistant pathogens. This work aimed to determine whether the analogs of depsidone, a natural product isolated from lichen, could be used as a potential treatment against Gram-positive and Gram-negative antibiotic resistant bacteria. Results showed that the core structure of the depsidone, 6,7,6-fused ring system, proved to be essential to the potency of the antibacterial activity. In this study, the methylated depsidone had 5% cell death against Pseudomonas aeruginosa. Structure activity relationship studies against various resistant bacteria, similar to Staphylococcus aureus strains, revealed that a suitable hydrophobic acyl tail in the phloroglucinol scaffold is a prerequisite for antibacterial activity.
How to Cite
Aguilar, A., (2022) “Evaluation of the Antibacterial Properties of Depsidones Against Pseudomonas aeruginosa”, Capstone, The UNC Asheville Journal of Undergraduate Scholarship 35(1).
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